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Trijec® Injection

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Antibiotics

Trijec® Injection

•Ceftriaxone 1 g.•Vial (1’s)

 

TRIJEC® is a third generation Cephalosporin which has broad spectrum bactericidal activity  by inhibiting mucopeptide synthesis in microorganism cell wall. TRIJEC® is effective against gram positive bacteria e.g. Streptococcus pneumoniae, Streptococcus group A (including Streptococcus pyogenes), Streptococcus group B (including Streptococcus agalactiae), Clostridium sp, Peptococcus sp, Peptostreptococcus sp, Staphylococcus aureus, Streptococcus viridans, Streptococcus bovis (group D) and also effective against gram negative bacteria e.g. Enterobacteriaceae, Eschericia coli, Haemophilus influenzae (including Ampicillin-resistant strain), Haemophilus parainfluenzae, Moraxella catarrhalis. Klebsiella sp, Enterobacter sp, Serratia marcescens, Proteus mirabilis, Citrobacter sp, Neisseria meningitidis, Neisseria gonorrhoeae (including penicillin-resistant  strain) indole positive Proteus, Salmonella  sp, Shigella  sp and  Yersinia  pestis.

 

Composition :

Each vial sterile powder for injection contains :

Ceftriaxone disodium 1,193 g equivalent to Ceftriaxone 1,0 g

Each ampoule contains aqua pro injection 10 ml

 

Indications :

Treatment of severe infections caused by organism sensitive to Ceftriaxone e.g. : sepsis, meningitis, lower respiration tract, genitourinary tract, septicemia, bone and joint infections, intra-abdominal infections, skin and soft tissue infections and post operative surgical prophylactic.

 

Dosage :

I.V. Injection : TRIJEC®  1 g dissolved in approximately 10 ml of water for injection and administered be accomplished slowly (2 - 4 minutes).

Adult : 1 - 2 g/day in 1 - 2 divided doses, in severe infections caused by moderate - sensitive organism maximum 4 g/day.

Children > 6 weeks : 20 - 50 mg/kg body weight/day.

Severe infections : maximum 80 mg/kg body weight/day, dosage > 50 mg/kg body weight only for i.v. infusion.

Post operative surgical infection : 1 g (0,5 - 2 hourly especially during surgery), 2 g pre colorectal surgical.

  • Duration of treatment varies depending on the cause of infections. Therapy must be continued for at least 48 - 72 hours after fever has subsided or significant improvement seen, usually after 4 - 14 days. If complication occur, duration of treatment may be longer. In infections caused by Streptococcus pyogenes, therapy must be continued for at least 10 days.

  • Renal and Liver Impairment

In patient with renal impairment, dosage reduction is not necessary if liver function normally. In prethermal-renal impairment (creatinine clearance < 10 ml/minutes) dosage should not exceed 2 g/day. In patient with liver impairment, dosage reduction is not necessary if kidney functions normally. In severe impairment both renal and liver, serum levels of Ceftriaxone must be monitored at regular periode. In patient with haemodialysis treatment, it is not necessary to increase the doses during haemodialysis period.

Special instruction

  • Meningitis

For infant and children, the initial dose of 100 mg/kg body weight (maximum 4 g) once a day should be given immediately after organism caused infections has identified and dosage may be decrease after sensitivity of organism well determined.

  • Duration of Treatment

Neisseria meningitis, 4 days.
Haemophilus influenzae, 6 days.
Streptococcus pneumoniae, 7 days.
Gonorrhea : single doses, 250 mg. I.m.

 

Contraindications :

  • Patient with known hypersensitivity to Cephalosporin.
  • Premature infants and neonates under 6 weeks.

 

Precautions and Warnings :

  • In colorectal surgical, to patient with renal and liver impairment, dosage should be reduce and serum levels of Ceftriaxone must be monitored.
  • Long term therapy may result into over growth of nonsusceptible microorganism.
  • Before therapy with Ceftriaxone is instituted, careful inquiry should be made to determine wether the patient has had previous hypersensitivity reaction (especially anaphylactic) to penicilline or another beta-lactam non Cephalosphorin drugs.
  • Caution for use in pregnant and nursing women.

 

 

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